Title : Role of α7-nicotinic acetylcholine receptor in nicotine-induced invasion and epithelial-to-mesenchymal transition in human non-small cell lung cancer cells.

Pub. Date : 2016 Sep 13

PMID : 27409670






2 Functional Relationships(s)
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1 Meanwhile, nicotine induced activation of MEK/ERK signaling in NSCLC cells; alpha7-nAChR antagonism or MEK/ERK signaling pathway inhibition suppressed NSCLC cell invasion and EMT marker expression. Nicotine mitogen-activated protein kinase kinase 7 Homo sapiens
2 These results indicate that nicotine induces NSCLC cell invasion, migration, and EMT; the effects are mediated by alpha7-nAChRs and involve MEK/ERK signaling pathway. Nicotine mitogen-activated protein kinase kinase 7 Homo sapiens