Title : A Novel Model of Dexamethasone-Induced Hypertension: Use in Investigating the Role of Tyrosine Hydroxylase.

Pub. Date : 2016 Sep

PMID : 27405316






1 Functional Relationships(s)
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1 To evaluate the involvement of tyrosine hydroxylase (TH), the rate-limiting step in catecholamine biosynthesis, we treated rats with the TH inhibitor, alpha-methyl-para-tyrosine (alpha-MPT), for 3 days prior to administration of DEX and assessed TH mRNA and protein expression by quantitative real-time polymerase chain reaction and Western blot in the adrenal medulla. Catecholamines tyrosine hydroxylase Rattus norvegicus