Title : An Autotaxin/Lysophosphatidic Acid/Interleukin-6 Amplification Loop Drives Scleroderma Fibrosis.

Pub. Date : 2016 Dec

PMID : 27390295






3 Functional Relationships(s)
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1 We used dermal fibroblasts from SSc patients and control subjects to evaluate LPA-induced expression of IL-6, and IL-6-induced expression of ATX. lysophosphatidic acid interleukin 6 Homo sapiens
2 Expression of both ATX and IL-6 was increased in SSc skin, and LPA-induced IL-6 levels and IL-6-induced ATX levels were increased in fibroblasts from SSc patients compared with controls. lysophosphatidic acid interleukin 6 Homo sapiens
3 Expression of both ATX and IL-6 was increased in SSc skin, and LPA-induced IL-6 levels and IL-6-induced ATX levels were increased in fibroblasts from SSc patients compared with controls. lysophosphatidic acid interleukin 6 Homo sapiens