Title : Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides.

Pub. Date : 2016 Aug 15

PMID : 27385778






2 Functional Relationships(s)
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1 These PM pores also facilitated the efflux of cytosolic ATP and influx of extracellular Ca(2+) Although lanthanides and Gsdmd deletion both suppressed PM pore activity and pyroptotic lysis, robust IL-1beta release was observed in lanthanide-treated BMDMs but not in Gsdmd-deficient cells. Adenosine Triphosphate gasdermin D Mus musculus
2 These PM pores also facilitated the efflux of cytosolic ATP and influx of extracellular Ca(2+) Although lanthanides and Gsdmd deletion both suppressed PM pore activity and pyroptotic lysis, robust IL-1beta release was observed in lanthanide-treated BMDMs but not in Gsdmd-deficient cells. Adenosine Triphosphate gasdermin D Mus musculus