| Protein Name | gasdermin D |
|---|---|
| Organism | Mus musculus |
| Gene ID | 69146 |
| Gene Symbol | Gsdmd |
| UniProt | Q9D8T2 (GSDMD_MOUSE), A0A679AXP3 (A0A679AXP3_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
140
Total Number of Articles : 142 |
Description |
gasdermin D |
| Gene Summary |
Enables phospholipid binding activity; transcription coactivator activity; and wide pore channel activity. Involved in several processes, including defense response to bacterium; positive regulation of interleukin-1 beta production; and protein-containing complex assembly. Acts upstream of or within several processes, including ceramide biosynthetic process; plasma membrane repair; and positive regulation of inflammatory response. Located in cytosol; extracellular space; and mitochondrial membrane. Part of NLRP3 inflammasome complex. Is active in plasma membrane. Is expressed in several structures, including aorta; gut; liver; metanephros; and spleen. Orthologous to human GSDMD (gasdermin D). [provided by Alliance of Genome Resources, Jun 2025] |
| synonyms |
|
| Properties | |