Pub. Date : 2016 Jul 28
PMID : 27374331
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | While many inflammatory responses to peptidoglycan are mediated by detection of its muramyl dipeptide component in the cytosol by NOD2, we report here that NLRP3 inflammasome activation is caused by release of N-acetylglucosamine that is detected in the cytosol by the glycolytic enzyme hexokinase. | Acetylglucosamine | hexokinase 1 | Homo sapiens |
| 2 | Inhibition of hexokinase by N-acetylglucosamine causes its dissociation from mitochondria outer membranes, and we found that this is sufficient to activate the NLRP3 inflammasome. | Acetylglucosamine | hexokinase 1 | Homo sapiens |