Title : Pim kinase inhibition sensitizes FLT3-ITD acute myeloid leukemia cells to topoisomerase 2 inhibitors through increased DNA damage and oxidative stress.

Pub. Date : 2016 Jul 26

PMID : 27374090






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Indeed, co-treatment with the pan-Pim kinase inhibitor AZD1208 or expression of a kinase-dead Pim-1 mutant sensitized FLT3-ITD cell lines to apoptosis triggered by chemotherapy drugs including the topoisomerase 2 inhibitors daunorubicin, etoposide and mitoxantrone, but not the nucleoside analog cytarabine. Daunorubicin fms related receptor tyrosine kinase 3 Homo sapiens