Pub. Date : 2016 Sep 2
PMID : 27363333
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Perfluorooctane sulfonate-induced insulin resistance is mediated by protein kinase B pathway. | perfluorooctane sulfonic acid | insulin | Homo sapiens |
| 2 | Perfluorooctane sulfonate (PFOS), a persistent organic pollutant, is blamed to be associated with the incidence of insulin resistance in the general human population. | perfluorooctane sulfonic acid | insulin | Homo sapiens |
| 3 | Perfluorooctane sulfonate (PFOS), a persistent organic pollutant, is blamed to be associated with the incidence of insulin resistance in the general human population. | perfluorooctane sulfonic acid | insulin | Homo sapiens |
| 4 | In this study, we found that PFOS inhibited the phosphorylation and activation of protein kinase B (AKT), a key mediator of cellular insulin sensitivity, in human hepatoma HepG2 cells. | perfluorooctane sulfonic acid | insulin | Homo sapiens |
| 5 | Eventually, the inhibition of AKT led to insulin resistance in PFOS-treated cells. | perfluorooctane sulfonic acid | insulin | Homo sapiens |