Title : Superior anti-tumor activity of the MDM2 antagonist idasanutlin and the Bcl-2 inhibitor venetoclax in p53 wild-type acute myeloid leukemia models.

Pub. Date : 2016 Jun 28

PMID : 27353420






1 Functional Relationships(s)
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1 As expected, gene expression studies using RNA sequencing showed significant alterations to pathways associated with p53 signaling and cell cycle arrest (CCND1 pathway) in response to idasanutlin treatment. RG7388 cyclin D1 Mus musculus