Pub. Date : 2016
PMID : 27340655
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Knockdown of PLC-gamma1, the downstream effector of PIP5K1alpha, blocked upstream dephosphorylation and PIP5K1alpha activation induced by calcium. | Calcium | phospholipase C gamma 1 | Homo sapiens |
| 2 | We have previously demonstrated that, following calcium stimulation, PIP5K1alpha is recruited by the E-cadherin-beta-catenin complex to the plasma membrane where it provides the substrate PIP2 for both PI3K and PLC-gamma1. | Calcium | phospholipase C gamma 1 | Homo sapiens |
| 3 | These results indicate that PP1 is recruited to the extracellular calcium-dependent E-cadherin-catenin-PIP5K1alpha complex in the plasma membrane to activate PIP5K1alpha, which is required for PLC-gamma1 activation leading to keratinocyte differentiation. | Calcium | phospholipase C gamma 1 | Homo sapiens |