Pub. Date : 2016 Oct
PMID : 27335232
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hydrogen Sulfide Induces Keap1 S-sulfhydration and Suppresses Diabetes-Accelerated Atherosclerosis via Nrf2 Activation. | Hydrogen Sulfide | kelch-like ECH-associated protein 1 | Mus musculus |
| 2 | H2S increased S-sulfhydration of Keap1, induced Nrf2 dissociation from Keap1, enhanced Nrf2 nuclear translocation, and inhibited O2 (-) generation, which were abrogated after Keap1 mutated at Cys151, but not Cys273, in endothelial cells. | Hydrogen Sulfide | kelch-like ECH-associated protein 1 | Mus musculus |
| 3 | H2S increased S-sulfhydration of Keap1, induced Nrf2 dissociation from Keap1, enhanced Nrf2 nuclear translocation, and inhibited O2 (-) generation, which were abrogated after Keap1 mutated at Cys151, but not Cys273, in endothelial cells. | Hydrogen Sulfide | kelch-like ECH-associated protein 1 | Mus musculus |
| 4 | H2S increased S-sulfhydration of Keap1, induced Nrf2 dissociation from Keap1, enhanced Nrf2 nuclear translocation, and inhibited O2 (-) generation, which were abrogated after Keap1 mutated at Cys151, but not Cys273, in endothelial cells. | Hydrogen Sulfide | kelch-like ECH-associated protein 1 | Mus musculus |
| 5 | Collectively, H2S attenuates diabetes-accelerated atherosclerosis, which may be related to inhibition of oxidative stress via Keap1 sulfhydrylation at Cys151 to activate Nrf2 signaling. | Hydrogen Sulfide | kelch-like ECH-associated protein 1 | Mus musculus |