Protein Name kelch-like ECH-associated protein 1
Organism Mus musculus
Gene ID 50868
Gene Symbol

Keap1

UniProt Q9Z2X8 (KEAP1_MOUSE)
Relationships Total Number of functionally related compound(s) : 383
Total Number of Articles : 413
Description

kelch-like ECH-associated protein 1

Gene Summary

Enables disordered domain specific binding activity and identical protein binding activity. Involved in cellular protein metabolic process; cellular response to oxidative stress; and regulation of autophagy. Acts upstream of or within several processes, including cellular response to interleukin-4; in utero embryonic development; and regulation of epidermal cell differentiation. Located in actin filament; endoplasmic reticulum; and inclusion body. Part of Cul3-RING ubiquitin ligase complex. Is expressed in eye and limb mesenchyme. Human ortholog(s) of this gene implicated in gallbladder cancer. Orthologous to human KEAP1 (kelch like ECH associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • kelch-like ECH-associated protein 1
  • NRF2 cytosolic inhibitor
  • cytosolic inhibitor of Nrf2
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Properties