Title : Isomeric iodinated analogs of nimesulide: Synthesis, physicochemical characterization, cyclooxygenase-2 inhibitory activity, and transport across Caco-2 cells.

Pub. Date : 2016 Aug 15

PMID : 27325447






1 Functional Relationships(s)
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1 Iodination at the ortho- or meta-position of the phenoxy ring was associated with a substantial loss of COX-2 inhibitory activity. Phenoxy radical prostaglandin-endoperoxide synthase 2 Homo sapiens