Pub. Date : 2016 Aug 9
PMID : 27322083
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Biochemical assays demonstrated that sphere-forming cells were shifted to pro-survival signaling through the inactivation of IRE1 (XBP-1 splicing) and activation of PERK (elF2alpha phosphorylation) branches under tunicamycin-induced ER stress conditions. | Tunicamycin | eukaryotic translation initiation factor 2 alpha kinase 3 | Homo sapiens |
| 2 | The proportion of apoptotic cells among sphere-forming cells was markedly increased by the tunicamycin+PERK inhibitor (PERKi) treatment, indicating that PERKi sensitized sphere-forming cells to tunicamycin-induced apoptosis. | Tunicamycin | eukaryotic translation initiation factor 2 alpha kinase 3 | Homo sapiens |