Pub. Date : 2016 Jun 20
PMID : 27321752
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In human inflammasome PCR array, among different involved in inflammasome formation, in HIV infected macrophages in the presence of cocaine, we have observed significant upregulation of NLRP3, AIM2 genes and downstream genes IL-1beta and PTGS2. | Cocaine | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | These results indicate that in case of HIV infected macrophages exposed to cocaine, increased ROS production and IL-1beta transcription serve as an activators for the formation of NLRP3 and AIM2 mediated inflammasomes that leads to caspase 1 mediated apoptosis. | Cocaine | NLR family pyrin domain containing 3 | Homo sapiens |