PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27321752-2 2016 In human inflammasome PCR array, among different involved in inflammasome formation, in HIV infected macrophages in the presence of cocaine, we have observed significant upregulation of NLRP3, AIM2 genes and downstream genes IL-1beta and PTGS2. Cocaine 132-139 NLR family pyrin domain containing 3 Homo sapiens 186-191 27321752-8 2016 These results indicate that in case of HIV infected macrophages exposed to cocaine, increased ROS production and IL-1beta transcription serve as an activators for the formation of NLRP3 and AIM2 mediated inflammasomes that leads to caspase 1 mediated apoptosis. Cocaine 75-82 NLR family pyrin domain containing 3 Homo sapiens 180-185