Pub. Date : 2016 Sep
PMID : 27317935
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, in DA-p53KO mice treated with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), we found that the induction of Bax and p53 up-regulated modulator of apoptosis (PUMA) mRNA and protein levels by MPTP were diminished in both striatum and substantia nigra of these mice. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | BCL2-associated X protein | Mus musculus |
| 2 | However, in DA-p53KO mice treated with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), we found that the induction of Bax and p53 up-regulated modulator of apoptosis (PUMA) mRNA and protein levels by MPTP were diminished in both striatum and substantia nigra of these mice. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | BCL2-associated X protein | Mus musculus |
| 3 | However, in DA-p53KO mice treated with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), we found that the induction of Bax and p53 up-regulated modulator of apoptosis (PUMA) mRNA and protein levels by MPTP were diminished in both striatum and substantia nigra of these mice. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | BCL2-associated X protein | Mus musculus |
| 4 | Our results further support the role of programmed cell death mediated by p53 in this animal model of PD and identify Bax, BAD and PUMA genes as downstream targets of p53 in modulating DA neuronal death in the in vivo MPTP-induced PD model. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | BCL2-associated X protein | Mus musculus |
| 5 | We deleted p53 gene in dopaminergic neurons in late developmental stages and found that DA specific p53 deletion is protective in acute MPTP animal model possibly through blocking MPTP-induced BAX and PUMA up-regulation. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | BCL2-associated X protein | Mus musculus |
| 6 | We deleted p53 gene in dopaminergic neurons in late developmental stages and found that DA specific p53 deletion is protective in acute MPTP animal model possibly through blocking MPTP-induced BAX and PUMA up-regulation. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | BCL2-associated X protein | Mus musculus |