Title : Carbon tetrachloride inhibits synthesis of pulmonary surfactant disaturated phosphatidylcholines and ATP production in alveolar type II cells.

Pub. Date : 1989 Jun 8

PMID : 2730887






3 Functional Relationships(s)
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Protein Name
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1 Exposure of alveolar type II cells to CCl4 does cause a rapid and dramatic loss in cellular ATP, a cofactor required by some enzymes involved in PC synthesis. Adenosine Triphosphate C-C motif chemokine ligand 4 Rattus norvegicus
2 Studies with isolated lung mitochondria suggest that CCl4 inhibits the enzyme complex which catalyzes the synthesis of ATP from ADP. Adenosine Triphosphate C-C motif chemokine ligand 4 Rattus norvegicus
3 The results of this study suggest that inhalation of CCl4 may impair surfactant phospholipid synthesis by decreasing ATP levels in alveolar type II cells. Adenosine Triphosphate C-C motif chemokine ligand 4 Rattus norvegicus