Title : Fluorofenidone attenuates pulmonary inflammation and fibrosis via inhibiting the activation of NALP3 inflammasome and IL-1β/IL-1R1/MyD88/NF-κB pathway.

Pub. Date : 2016 Nov

PMID : 27306439






2 Functional Relationships(s)
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1 Fluorofenidone attenuates pulmonary inflammation and fibrosis via inhibiting the activation of NALP3 inflammasome and IL-1beta/IL-1R1/MyD88/NF-kappaB pathway. 5-methyl-1-(3-fluorophenyl)-2-(1H)-pyridone myeloid differentiation primary response gene 88 Mus musculus
2 In this study, we explored whether a potential anti-fibrotic agent fluorofenidone (FD) exerts its anti-inflammatory and anti-fibrotic effects through suppressing activation of NACHT, LRR and PYD domains-containing protein 3 (NALP3) inflammasome and the IL-1beta/IL-1R1/MyD88/NF-kappaB pathway in vivo and in vitro. 5-methyl-1-(3-fluorophenyl)-2-(1H)-pyridone myeloid differentiation primary response gene 88 Mus musculus