Pub. Date : 2016 Jun 28
PMID : 27298359
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Based on these new findings, here we have successfully introduced high-affinity binding of capsaicin and resiniferatoxin to the vanilloid-insensitive TRPV2 channel, using a rationally designed minimal set of four point mutations (F467S-S498F-L505T-Q525E, termed TRPV2_Quad). | resiniferatoxin | transient receptor potential cation channel subfamily V member 2 | Homo sapiens |
| 2 | Based on these new findings, here we have successfully introduced high-affinity binding of capsaicin and resiniferatoxin to the vanilloid-insensitive TRPV2 channel, using a rationally designed minimal set of four point mutations (F467S-S498F-L505T-Q525E, termed TRPV2_Quad). | resiniferatoxin | transient receptor potential cation channel subfamily V member 2 | Homo sapiens |
| 3 | We found that binding of resiniferatoxin activates TRPV2_Quad but the ligand-induced open state is relatively unstable, whereas binding of capsaicin to TRPV2_Quad antagonizes resiniferatoxin-induced activation likely through competition for the same binding sites. | resiniferatoxin | transient receptor potential cation channel subfamily V member 2 | Homo sapiens |
| 4 | We found that binding of resiniferatoxin activates TRPV2_Quad but the ligand-induced open state is relatively unstable, whereas binding of capsaicin to TRPV2_Quad antagonizes resiniferatoxin-induced activation likely through competition for the same binding sites. | resiniferatoxin | transient receptor potential cation channel subfamily V member 2 | Homo sapiens |