PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27298359-3	2016	Based on these new findings, here we have successfully introduced high-affinity binding of capsaicin and resiniferatoxin to the vanilloid-insensitive TRPV2 channel, using a rationally designed minimal set of four point mutations (F467S-S498F-L505T-Q525E, termed TRPV2_Quad).	resiniferatoxin	105-120	transient receptor potential cation channel subfamily V member 2	Homo sapiens	150-155	
27298359-3	2016	Based on these new findings, here we have successfully introduced high-affinity binding of capsaicin and resiniferatoxin to the vanilloid-insensitive TRPV2 channel, using a rationally designed minimal set of four point mutations (F467S-S498F-L505T-Q525E, termed TRPV2_Quad).	resiniferatoxin	105-120	transient receptor potential cation channel subfamily V member 2	Homo sapiens	262-267	
27298359-4	2016	We found that binding of resiniferatoxin activates TRPV2_Quad but the ligand-induced open state is relatively unstable, whereas binding of capsaicin to TRPV2_Quad antagonizes resiniferatoxin-induced activation likely through competition for the same binding sites.	resiniferatoxin	25-40	transient receptor potential cation channel subfamily V member 2	Homo sapiens	51-56	
27298359-4	2016	We found that binding of resiniferatoxin activates TRPV2_Quad but the ligand-induced open state is relatively unstable, whereas binding of capsaicin to TRPV2_Quad antagonizes resiniferatoxin-induced activation likely through competition for the same binding sites.	resiniferatoxin	175-190	transient receptor potential cation channel subfamily V member 2	Homo sapiens	152-157