Title : Hepatic radiofrequency ablation: markedly reduced systemic effects by modulating periablational inflammation via cyclooxygenase-2 inhibition.

Pub. Date : 2017 Mar

PMID : 27287478






4 Functional Relationships(s)
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1 OBJECTIVES: To determine whether celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, can potentiate hepatic radiofrequency ablation (RFA)-induced local cellular infiltration and distant tumour growth. Celecoxib prostaglandin-endoperoxide synthase 2 Rattus norvegicus
2 OBJECTIVES: To determine whether celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, can potentiate hepatic radiofrequency ablation (RFA)-induced local cellular infiltration and distant tumour growth. Celecoxib prostaglandin-endoperoxide synthase 2 Rattus norvegicus
3 RESULTS: Hepatic RFA-induced local activation of COX-2 was significantly suppressed using celecoxib. Celecoxib prostaglandin-endoperoxide synthase 2 Rattus norvegicus
4 Local COX-2 inhibition with celecoxib can block ablation-induced distant tumour growth. Celecoxib prostaglandin-endoperoxide synthase 2 Rattus norvegicus