Title : Uncoupling protein 2 regulates metabolic reprogramming and fate of antigen-stimulated CD8+ T cells.

Pub. Date : 2016 Jul

PMID : 27271549






1 Functional Relationships(s)
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1 Employing genetic (siRNA) and pharmacologic (Genipin) approaches, we note that antigen-induced UCP2 expression reduces glycolysis, fatty acid synthesis and production of reactive oxygen species to balance differentiation with survival of effector CD8+ T cells. Reactive Oxygen Species uncoupling protein 2 Homo sapiens