Protein Name uncoupling protein 2
Organism Homo sapiens
Gene ID 7351
Gene Symbol


UniProt P55851 (UCP2_HUMAN), A0A024R5N5 (A0A024R5N5_HUMAN)
Relationships Total Number of functionally related compound(s) : 290
Total Number of Articles : 440

uncoupling protein 2

Gene Summary

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008]

  • dicarboxylate carrier SLC25A8
  • mitochondrial uncoupling protein 2
  • solute carrier family 25 member 8
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