Title : Single-Molecule Patch-Clamp FRET Anisotropy Microscopy Studies of NMDA Receptor Ion Channel Activation and Deactivation under Agonist Ligand Binding in Living Cells.

Pub. Date : 2016 Jul 20

PMID : 27270213






1 Functional Relationships(s)
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1 Single-channel patch-clamp and four-channel fluorescence measurement are recorded simultaneously to get correlation among electrical on and off states, optically determined conformational open and closed states by FRET, and binding-unbinding states of the glycine ligand by anisotropy measurement at the ligand binding domain of GluN1 subunit. Glycine glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens