Pub. Date : 2016 Sep
PMID : 27256378
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ibrutinib treatment impacts HER2(+) breast cancer cell viability at lower concentrations than the established breast cancer therapeutic lapatinib. | ibrutinib | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 2 | In addition to inhibiting BTK, ibrutinib, but not AVL-292 and CGI-1746, efficiently blocks the activation of EGFR, HER2, ErbB3, and ErbB4. | ibrutinib | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 3 | HER2(+) breast cancer cell proliferation is blocked by ibrutinib even in the presence of these factors. | ibrutinib | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 4 | In vivo, ibrutinib inhibits HER2(+) xenograft tumor growth. | ibrutinib | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 5 | Consistent with this, immunofluorescence analysis of xenograft tumors shows that ibrutinib reduces the phosphorylation of HER2, BTK, Akt, and Erk and histone H3 and increases cleaved caspase-3 signals. | ibrutinib | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 6 | As BTK-C and HER2 are often coexpressed in human breast cancers, these observations indicate that BTK-C is a potential therapeutic target and that ibrutinib could be an effective drug especially for HER2(+) breast cancer. | ibrutinib | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 7 | As BTK-C and HER2 are often coexpressed in human breast cancers, these observations indicate that BTK-C is a potential therapeutic target and that ibrutinib could be an effective drug especially for HER2(+) breast cancer. | ibrutinib | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |