Title : Short Term Palmitate Supply Impairs Intestinal Insulin Signaling via Ceramide Production.

Pub. Date : 2016 Jul 29

PMID : 27255710






4 Functional Relationships(s)
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1 Moreover, when mouse intestine and human Caco-2/TC7 enterocytes were treated with the saturated fatty acid, palmitic acid, the insulin-signaling pathway was impaired. Palmitic Acid insulin Homo sapiens
2 We show that palmitic acid or palm oil increases ceramide production in intestinal cells and that treatment with a ceramide analogue partially reproduces the effects of palmitic acid on insulin signaling. Palmitic Acid insulin Homo sapiens
3 We show that palmitic acid or palm oil increases ceramide production in intestinal cells and that treatment with a ceramide analogue partially reproduces the effects of palmitic acid on insulin signaling. Palmitic Acid insulin Homo sapiens
4 Finally, inhibiting de novo ceramide synthesis improves the response of palmitic acid-treated Caco-2/TC7 enterocytes to insulin. Palmitic Acid insulin Homo sapiens