Title : Glycines from the APP GXXXG/GXXXA Transmembrane Motifs Promote Formation of Pathogenic Aβ Oligomers in Cells.

Pub. Date : 2016

PMID : 27242518






3 Functional Relationships(s)
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1 Glycines from the APP GXXXG/GXXXA Transmembrane Motifs Promote Formation of Pathogenic Abeta Oligomers in Cells. Glycine amyloid beta precursor protein Homo sapiens
2 Glycine-to-leucine mutations of these motifs were previously shown to affect APP processing and Abeta production in cells. Glycine amyloid beta precursor protein Homo sapiens
3 By a point-mutation approach, we demonstrate that glycine-to-leucine mutations in the G(29)XXXG(33) and G(38)XXXA(42) motifs dramatically affect the Abeta oligomerization process. Glycine amyloid beta precursor protein Homo sapiens