Pub. Date : 2016
PMID : 27242518
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Glycines from the APP GXXXG/GXXXA Transmembrane Motifs Promote Formation of Pathogenic Abeta Oligomers in Cells. | Glycine | amyloid beta precursor protein | Homo sapiens |
2 | Glycine-to-leucine mutations of these motifs were previously shown to affect APP processing and Abeta production in cells. | Glycine | amyloid beta precursor protein | Homo sapiens |
3 | By a point-mutation approach, we demonstrate that glycine-to-leucine mutations in the G(29)XXXG(33) and G(38)XXXA(42) motifs dramatically affect the Abeta oligomerization process. | Glycine | amyloid beta precursor protein | Homo sapiens |