Title : SP600125 enhances the anti-apoptotic capacity and migration of bone marrow mesenchymal stem cells treated with tumor necrosis factor-α.

Pub. Date : 2016 Jul 8

PMID : 27233606






2 Functional Relationships(s)
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1 In the presence of SP600125, expression of cleaved caspase-9/-3 and p53 as well as the ratio of Bax to Bcl-2 was significantly decreased compared to treatment with TNF-alpha alone. pyrazolanthrone caspase 9 Homo sapiens
2 Our results therefore indicate that SP600125 improves the migration capacity of TNF-alpha-treated BMSCs and exerts a significant effect on the viability of TNF-alpha-treated BMSCs through reducing the up-regulation of p53, caspase-9/-3 and the Bcl-2 family induced by TNF-alpha. pyrazolanthrone caspase 9 Homo sapiens