Title : Inhibitory effect of extracellular purine nucleotide and nucleoside concentrations on T cell proliferation.

Pub. Date : 2016 Nov 15

PMID : 27233214






1 Functional Relationships(s)
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1 In contrast to RPMI1640, X-Vivo15 resulted in a significant down-regulation of the cell-surface-located ectonucleotidases CD39 (Ecto-Apyrase) and CD73 (Ecto-5"-Nucleotidase), critical for the extracellular nucleotides-hydrolysis to nucleosides, explaining the loss of inhibition mediated by dGTP and GTP, but not Guanosine. Nucleosides 5'-nucleotidase ecto Homo sapiens