Title : A novel amino acid substitution in the reactive site of a congenital variant antithrombin. Antithrombin pescara, ARG393 to pro, caused by a CGT to CCT mutation.

Pub. Date : 1989 Jun 15

PMID : 2722864






1 Functional Relationships(s)
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1 Accordingly, we have isolated the variant from plasma using heparin-Sepharose chromatography, followed by chromatography upon thrombin-Sepharose to remove the normal antithrombin that is present (the propositus is heterozygous for the variant). Sepharose coagulation factor II, thrombin Homo sapiens