Title : MicroRNA-1301-Mediated RanGAP1 Downregulation Induces BCR-ABL Nuclear Entrapment to Enhance Imatinib Efficacy in Chronic Myeloid Leukemia Cells.

Pub. Date : 2016

PMID : 27228340






1 Functional Relationships(s)
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1 Furthermore, immunofluorescence assay demonstrated that Tyr-99 of nuclear P73 was phosphorylated accompanied with nuclear entrapment of BCR-ABL after transfection with RanGAP1 shRNA or miR-1301 in IM-treated K562 cells. Tyrosine ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens