Title : Curcumin inhibits lipolysis via suppression of ER stress in adipose tissue and prevents hepatic insulin resistance.

Pub. Date : 2016 Jul

PMID : 27220352






3 Functional Relationships(s)
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1 Curcumin reduced FFA influx into the liver by blocking FFA trafficking, and then prevented diacylglycerol deposits and PKCepsilon translocation in the liver, resultantly improving insulin action in the suppression of hepatic gluconeogenesis. Curcumin insulin Homo sapiens
2 Curcumin decreased adipose lipolysis by attenuating ER stress through the cAMP/PKA pathway, reduced FFA influx into the liver by blocking FFA trafficking, and thereby improved insulin sensitivity to inhibit hepatic glucose production. Curcumin insulin Homo sapiens
3 These findings suggested a novel pathway of curcumin to prevent lipid deposits and insulin resistance in liver by beneficial regulation of adipose function. Curcumin insulin Homo sapiens