Pub. Date : 2016
PMID : 27211318
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Genistein upregulates LDLR levels via JNK-mediated activation of SREBP-2. | Genistein | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | The genistein-phosphorylated JNK inhibitor (SP600126) abolished the genistein-stimulated levels of LDLR and the nuclear SREBP-2. | Genistein | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | The genistein-phosphorylated JNK inhibitor (SP600126) abolished the genistein-stimulated levels of LDLR and the nuclear SREBP-2. | Genistein | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | CONCLUSION: Our data support the idea that genistein may have anti-atherogenic effects by activating JNK signals and SREBP-2 processing, which is followed by the upregulation of LDLR. | Genistein | mitogen-activated protein kinase 8 | Homo sapiens |