Title : The Mouse Fetal Ovary Has Greater Sensitivity Than the Fetal Testis to Benzo[a]pyrene-Induced Germ Cell Death.

Pub. Date : 2016 Aug

PMID : 27208085






2 Functional Relationships(s)
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1 Treatment with BaP elevated the expression of BAX protein at 6 h and activated downstream caspases-9 and -3 at 24 h in a concentration-dependent manner in germ cells of fetal ovaries. Benzo(a)pyrene BCL2-associated X protein Mus musculus
2 Our findings show that BaP exposure increases caspase-dependent and BAX-associated germ cell apoptosis in the mouse fetal ovary, leading to germ cell depletion. Benzo(a)pyrene BCL2-associated X protein Mus musculus