Title : Rictor/mTORC2 Drives Progression and Therapeutic Resistance of HER2-Amplified Breast Cancers.

Pub. Date : 2016 Aug 15

PMID : 27197158






1 Functional Relationships(s)
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1 In HER2-amplified cells, exposure to an mTORC1/2 dual kinase inhibitor decreased Akt-dependent cell survival, including in cells resistant to lapatinib, where cytotoxicity could be restored. Lapatinib erb-b2 receptor tyrosine kinase 2 Mus musculus