Title : Activation of concurrent apoptosis and necroptosis by SMAC mimetics for the treatment of refractory and relapsed ALL.

Pub. Date : 2016 May 18

PMID : 27194728






1 Functional Relationships(s)
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1 Thus, SM compounds such as birinapant circumvent escape from apoptosis in leukemia by activating a potent dual RIP1-dependent apoptotic and necroptotic cell death, which is not exploited by current therapy. birinapant receptor interacting serine/threonine kinase 1 Homo sapiens