Protein Name receptor interacting serine/threonine kinase 1
Organism Homo sapiens
Gene ID 8737
Gene Symbol

RIPK1

UniProt Q13546 (RIPK1_HUMAN), A0A024QZU0 (A0A024QZU0_HUMAN)
Relationships Total Number of functionally related compound(s) : 356
Total Number of Articles : 451
Description

receptor interacting serine/threonine kinase 1

Gene Summary

This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell death in response to tissue damage, pathogen recognition, and as part of developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is referred to as necroptosis. Genetic disruption of this gene in mice results in death shortly after birth. [provided by RefSeq, Aug 2017]

synonyms
  • receptor-interacting serine/threonine-protein kinase 1
  • cell death protein RIP
  • receptor (TNFRSF)-interacting serine-threonine kinase 1
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Properties