Title : Activation of concurrent apoptosis and necroptosis by SMAC mimetics for the treatment of refractory and relapsed ALL.

Pub. Date : 2016 May 18

PMID : 27194728






1 Functional Relationships(s)
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1 Potent ex vivo activity of the SMAC mimetic (SM) birinapant correlated with marked in vivo antileukemic effects, as indicated by delayed engraftment, decreased leukemia burden, and prolonged survival of xenografted mice. birinapant diablo, IAP-binding mitochondrial protein Mus musculus