Title : Reduced levels of dopamine and altered metabolism in brains of HPRT knock-out rats: a new rodent model of Lesch-Nyhan Disease.

Pub. Date : 2016 May 17

PMID : 27185277






2 Functional Relationships(s)
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1 Lesch-Nyhan disease (LND) is a severe neurological disorder caused by loss-of-function mutations in the gene encoding hypoxanthine phosphoribosyltransferase (HPRT), an enzyme required for efficient recycling of purine nucleotides. Purine Nucleotides hypoxanthine phosphoribosyltransferase 1 Rattus norvegicus
2 Lesch-Nyhan disease (LND) is a severe neurological disorder caused by loss-of-function mutations in the gene encoding hypoxanthine phosphoribosyltransferase (HPRT), an enzyme required for efficient recycling of purine nucleotides. Purine Nucleotides hypoxanthine phosphoribosyltransferase 1 Rattus norvegicus