PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27172402-0 2016 BAX-BAK1-independent LC3B lipidation by BH3 mimetics is unrelated to BH3 mimetic activity and has only minimal effects on autophagic flux. BH 3 40-43 BCL2 associated X, apoptosis regulator Homo sapiens 0-8 27172402-3 2016 Here we confirm that small molecule BH3 mimetics can induce BAX- and BAK1-independent MAP1LC3B/LC3B lipidation, but this only occurred at concentrations far greater than required to induce apoptosis and dissociate canonical BH3 domain-containing proteins that bind more tightly than BECN1. BH 3 36-39 BCL2 associated X, apoptosis regulator Homo sapiens 60-63 27172402-6 2016 Therefore at concentrations that are on target and achievable in vivo, BH3 mimetics only induce autophagy in a BAX- and BAK1-dependent manner. BH 3 71-74 BCL2 associated X, apoptosis regulator Homo sapiens 111-114