Title : Glucosylceramide synthase inhibitors D-PDMP and D-EtDO-P4 decrease the GM3 ganglioside level, differ in their effects on insulin receptor autophosphorylation but increase Akt1 kinase phosphorylation in human hepatoma HepG2 cells.

Pub. Date : 2016

PMID : 27172362






2 Functional Relationships(s)
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1 Glucosylceramide synthase inhibitors D-PDMP and D-EtDO-P4 decrease the GM3 ganglioside level, differ in their effects on insulin receptor autophosphorylation but increase Akt1 kinase phosphorylation in human hepatoma HepG2 cells. 3',4'-ethylenedioxyphenyl-2-palmitoylamino-3-pyrrolidino-1-propanol insulin receptor Homo sapiens
2 The effect of d-EtDO-P4 on IR autophosphorylation was smaller amounting to an increase by 134.8% (111.3-167.8%) of the control level and statistically non-significant. 3',4'-ethylenedioxyphenyl-2-palmitoylamino-3-pyrrolidino-1-propanol insulin receptor Homo sapiens