Title : Protein Kinases Alter the Allosteric Modulation of the Serotonin Transporter In Vivo and In Vitro.

Pub. Date : 2016 Aug

PMID : 27171685






6 Functional Relationships(s)
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1 AIM: Studies using S- and R-enantiomers of the SSRI citalopram have shown that R-citalopram exerts an antagonistic effect on the efficacy of the antidepressant S-citalopram (escitalopram) through an interaction at an allosteric modulator site on the serotonin transporter (SERT). Citalopram solute carrier family 6 member 4 Rattus norvegicus
2 AIM: Studies using S- and R-enantiomers of the SSRI citalopram have shown that R-citalopram exerts an antagonistic effect on the efficacy of the antidepressant S-citalopram (escitalopram) through an interaction at an allosteric modulator site on the serotonin transporter (SERT). Citalopram solute carrier family 6 member 4 Rattus norvegicus
3 AIM: Studies using S- and R-enantiomers of the SSRI citalopram have shown that R-citalopram exerts an antagonistic effect on the efficacy of the antidepressant S-citalopram (escitalopram) through an interaction at an allosteric modulator site on the serotonin transporter (SERT). Citalopram solute carrier family 6 member 4 Rattus norvegicus
4 AIM: Studies using S- and R-enantiomers of the SSRI citalopram have shown that R-citalopram exerts an antagonistic effect on the efficacy of the antidepressant S-citalopram (escitalopram) through an interaction at an allosteric modulator site on the serotonin transporter (SERT). Citalopram solute carrier family 6 member 4 Rattus norvegicus
5 Finally, in vitro, quantification of the amount of cell surface-expressed SERT molecules revealed that R-citalopram prevented escitalopram-induced SERT internalization that was completely altered by staurosporine. Citalopram solute carrier family 6 member 4 Rattus norvegicus
6 Finally, in vitro, quantification of the amount of cell surface-expressed SERT molecules revealed that R-citalopram prevented escitalopram-induced SERT internalization that was completely altered by staurosporine. Citalopram solute carrier family 6 member 4 Rattus norvegicus