Pub. Date : 2016 Jun 25
PMID : 27163851
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In vitro metabolism of phenytoin in 36 CYP2C9 variants found in the Chinese population. | Phenytoin | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 2 | This study aims to assess the catalytic activities of wild-type (CYP2C9*1) and 36 CYP2C9 allelic variants found in the Chinese population toward phenytoin (PHT) in vitro. | Phenytoin | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 3 | This study aims to assess the catalytic activities of wild-type (CYP2C9*1) and 36 CYP2C9 allelic variants found in the Chinese population toward phenytoin (PHT) in vitro. | Phenytoin | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 4 | This study aims to assess the catalytic activities of wild-type (CYP2C9*1) and 36 CYP2C9 allelic variants found in the Chinese population toward phenytoin (PHT) in vitro. | Phenytoin | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 5 | This study aims to assess the catalytic activities of wild-type (CYP2C9*1) and 36 CYP2C9 allelic variants found in the Chinese population toward phenytoin (PHT) in vitro. | Phenytoin | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 6 | Insect microsomes expressing CYP2C9*1 and 36 CYP2C9 variants were incubated with 1-200 muM phenytoin for 30 min at 37 C. Then, these products were extracted and the signal detection was performed by HPLC-MS/MS. | Phenytoin | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 7 | Insect microsomes expressing CYP2C9*1 and 36 CYP2C9 variants were incubated with 1-200 muM phenytoin for 30 min at 37 C. Then, these products were extracted and the signal detection was performed by HPLC-MS/MS. | Phenytoin | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 8 | The findings suggest that more attention should be paid on subjects carrying these infrequent CYP2C9 alleles when administering phenytoin in clinic. | Phenytoin | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |