Pub. Date : 2015 Dec
PMID : 27162518
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | VITAMIN B12 LEVELS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS ON METFORMIN. | Metformin | NADH:ubiquinone oxidoreductase subunit B3 | Homo sapiens |
| 2 | BACKGROUND: Due to the clinical benefits of metformin, its associated side effects such as vitamin B12 deficiency are usually overlooked and rarely investigated. | Metformin | NADH:ubiquinone oxidoreductase subunit B3 | Homo sapiens |
| 3 | OBJECTIVE: This study was carried out to determine the serum level of vitamin B12 in Nigerian patients with type 2 diabetes mellitus (T2DM) on metformin. | Metformin | NADH:ubiquinone oxidoreductase subunit B3 | Homo sapiens |
| 4 | METHODS: Serum vitamin B12 level was determined using high performance liquid chromatography (HPLC) in 81 T2DM patients who have been on metformin for 5 years or more. | Metformin | NADH:ubiquinone oxidoreductase subunit B3 | Homo sapiens |
| 5 | Vitamin B12 level was significantly lower in patients who have been on metformin for >=10 years compared with patients with <10 years history of metformin use. | Metformin | NADH:ubiquinone oxidoreductase subunit B3 | Homo sapiens |
| 6 | Vitamin B12 level was significantly lower in patients who have been on metformin for >=10 years compared with patients with <10 years history of metformin use. | Metformin | NADH:ubiquinone oxidoreductase subunit B3 | Homo sapiens |
| 7 | Similarly, patients who were on metformin at a dose of >1000 mg/day had significantly lower vitamin B12 level when compared with patients on <=1000 mg/day. | Metformin | NADH:ubiquinone oxidoreductase subunit B3 | Homo sapiens |
| 8 | CONCLUSION: Low serum vitamin B12 level is associated with longer duration and higher dose of metformin use. | Metformin | NADH:ubiquinone oxidoreductase subunit B3 | Homo sapiens |
| 9 | Therefore, routine determination of vitamin B12 level in patients with T2DM on high dose of metformin and those with prolonged use of metformin might help in identifying patients that would benefit from vitamin B12 supplements. | Metformin | NADH:ubiquinone oxidoreductase subunit B3 | Homo sapiens |
| 10 | Therefore, routine determination of vitamin B12 level in patients with T2DM on high dose of metformin and those with prolonged use of metformin might help in identifying patients that would benefit from vitamin B12 supplements. | Metformin | NADH:ubiquinone oxidoreductase subunit B3 | Homo sapiens |