Title : In vivo chronic nicotine exposure differentially and reversibly affects upregulation and stoichiometry of α4β2 nicotinic receptors in cortex and thalamus.

Pub. Date : 2016 Sep

PMID : 27157710






3 Functional Relationships(s)
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1 Studies with heterologous expression systems have shown that the alpha4beta2 nicotinic acetylcholine receptor (nAChR) subtype can exist in two stoichiometries (with two [(alpha4)2(beta2)3] or three [(alpha4)3(beta2)2] copies of the alpha subunit in the receptor pentamer) which have different pharmacological and functional properties and are differently regulated by chronic nicotine treatment. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
2 However, the effects of nicotine treatment in vivo on native alpha4beta2 nAChR stoichiometry are not well known. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
3 These data suggest that chronic nicotine exposure in vivo favors increased assembly of alpha4beta2 nAChR containing three beta2 subunits. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus