Pub. Date : 2016 Jul
PMID : 27146480
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cholesterol 7alpha-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders. | Cholesterol | cytochrome P450, family 7, subfamily a, polypeptide 1 | Mus musculus |
| 2 | Cholesterol 7alpha-hydroxylase (CYP7A1) is the first and rate-limiting enzyme in the conversion of cholesterol to bile acids in the liver. | Cholesterol | cytochrome P450, family 7, subfamily a, polypeptide 1 | Mus musculus |
| 3 | Cholesterol 7alpha-hydroxylase (CYP7A1) is the first and rate-limiting enzyme in the conversion of cholesterol to bile acids in the liver. | Cholesterol | cytochrome P450, family 7, subfamily a, polypeptide 1 | Mus musculus |
| 4 | Surprisingly, Cyp7a1(-/-) mice have improved glucose sensitivity with reduced liver triglycerides and fecal bile acid excretion, but increased fecal fatty acid excretion and respiratory exchange ratio (RER) when fed a high-fat/high-cholesterol diet. | Cholesterol | cytochrome P450, family 7, subfamily a, polypeptide 1 | Mus musculus |