Title : Grape seed proanthocyanidins protects against cadmium induced oxidative pancreatitis in rats by attenuating oxidative stress, inflammation and apoptosis via Nrf-2/HO-1 signaling.

Pub. Date : 2016 Jun

PMID : 27142746






2 Functional Relationships(s)
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1 Grape seed proanthocyanidins protects against cadmium induced oxidative pancreatitis in rats by attenuating oxidative stress, inflammation and apoptosis via Nrf-2/HO-1 signaling. Cadmium heme oxygenase 1 Rattus norvegicus
2 Cd intoxication revealed increased levels of proinflammatory cytokines (TNF-alpha, IL1beta and IFN-gamma), reduced levels of cellular defense proteins (Nrf-2 and HO-1) and glucose transporter (GLUT-2 and GLUT-4) along with the enhanced levels of signaling molecules of apoptosis (cleaved Caspase-12/9/8/3) in the pancreas of Cd-intoxicated rats. Cadmium heme oxygenase 1 Rattus norvegicus