Title : The combination of 1α,25dihydroxyvitaminD3 with resveratrol improves neuronal degeneration by regulating endoplasmic reticulum stress, insulin signaling and inhibiting tau hyperphosphorylation in SH-SY5Y cells.

Pub. Date : 2016 Jul

PMID : 27133915






1 Functional Relationships(s)
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1 The combination of vitamin D & resveratrol completely reversed tunicamycin and Abeta25-35 induced cytotoxicity in SH-SY5Y cells, as well as elevation in ER stress markers (i.e.GRP78, p-eIF2alpha and CHOP), insulin signaling disruption (i.e. elevation in p-IRS-1serine307 and reduction in p-Akt serine473) and tau phosphorylation (i.e. reduction in p-GSK3beta serine9, and elevation in p-Tau serine396 &404). Resveratrol DNA damage inducible transcript 3 Homo sapiens