Title : Evaluation of the effect of fluconazole and ketoconazole on the pharmacokinetics of tofacitinib in healthy adult subjects.

Pub. Date : 2014 Jan

PMID : 27128233






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Tofacitinib is predominantly metabolized by cytochrome P450 (CYP) 3A4 and to a lesser extent by CYP2C19. tofacitinib cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Co-administration of moderate to potent CYP3A4 inhibitors is likely to increase the systemic exposure of tofacitinib and thus may warrant dosage adjustments or restrictions. tofacitinib cytochrome P450 family 3 subfamily A member 4 Homo sapiens